Genesis Mission: Trump's Executive Order Launches National AI Effort To Accelerate Scientific Discovery

President Donald Trump signed an executive order "Launching the Genesis Mission," Monday, launching the "Genesis Mission," a national effort to accelerate scientific discovery through artificial intelligence by building an integrated AI platform using federal scientific datasets, supercomputing resources, and AI agents to automate research workflows and test new hypotheses.

The initiative, described as comparable in urgency and ambition to the Manhattan Project, aims to harness the world’s largest collection of federal scientific datasets to train foundation models and create AI agents that can accelerate breakthroughs in areas like biotechnology, nuclear fusion, and advanced manufacturing.

"This order launches the 'Genesis Mission' as a dedicated, coordinated national effort to unleash a new age of AI‑accelerated innovation and discovery that can solve the most challenging problems of this century," the order reads. "The Genesis Mission will build an integrated AI platform to harness Federal scientific datasets — the world’s largest collection of such datasets, developed over decades of Federal investments — to train scientific foundation models and create AI agents to test new hypotheses, automate research workflows, and accelerate scientific breakthroughs.

"The Genesis Mission will bring together our Nation’s research and development resources — combining the efforts of brilliant American scientists, including those at our national laboratories, with pioneering American businesses; world-renowned universities; and existing research infrastructure, data repositories, production plants, and national security sites — to achieve dramatic acceleration in AI development and utilization.

"We will harness for the benefit of our Nation the revolution underway in computing, and build on decades of innovation in semiconductors and high-performance computing. The Genesis Mission will dramatically accelerate scientific discovery, strengthen national security, secure energy dominance, enhance workforce productivity, and multiply the return on taxpayer investment into research and development, thereby furthering America’s technological dominance and global strategic leadership."

The Genesis Mission is directed by the Secretary of Energy, who is tasked with establishing the "American Science and Security Platform" as the technical backbone of the mission. This platform will integrate high-performance computing resources, AI modeling frameworks, computational tools, domain-specific foundation models, and secure access to federal, academic, and private-sector datasets.

With the Genesis Mission, which will be run out of the Department of Energy (DoE) but under the oversight of the Assistant to the President for Science and Technology, Michael Kratsios, Trump is codifying an effort he began months ago when he started announcing billions in private sector AI company investments.

The order mandates specific deadlines: the Secretary of Energy must identify computing resources within 90 days, initial data and model assets within 120 days, assess robotic laboratories and production facilities within 240 days, and demonstrate an initial operating capability for at least one national challenge within 270 days.

Within 60 days, the Secretary must identify at least 20 science and technology challenges of national importance, including advanced manufacturing, biotechnology, critical materials, nuclear fission and fusion, quantum information science, and semiconductors and microelectronics.

The initiative is framed as a strategic response to global technology competition, positioning AI as central to long-term U.S. national security and economic leadership. It emphasizes public-private collaboration, with significant interest already reported from companies like Nvidia, Dell, AMD, and HPE.

The Genesis Mission builds upon existing federal efforts like the National Artificial Intelligence Research Resource (NAIRR) and recent partnerships with tech companies to expand supercomputing capacity, including new systems at Oak Ridge National Laboratory. It is "a national effort to accelerate the application of AI for transformative scientific discovery focused on pressing national challenges," the executive order reads.